Ligne de temps

Grazyna Faure-Kuzminska

Chercheur(euse) Permanent(e)

22 déc. 2022

publication

Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

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13 nov. 2020

publication

Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.

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13 nov. 2018

event

25th Meeting (RT25) of the French Society of Toxinology (SFET) : “Toxins and Health: from Molecules to Organisms”.

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28 févr. 2018

patent

Rattlesnake Phospholipase A2 increases CFTR-chloride channel current and corrects DF508CFTR dysfunction providing scaffold for chemical synthesis of dual modulators correctiong DF508CFTR ; application to treatment of Cystic Fibrosis

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30 nov. 2017

publication

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

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12 oct. 2017

publication

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors

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14 avr. 2017

event

Neuroscience – unité Récepteurs-Canaux Lab Seminar

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01 févr. 2017

publication

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8

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15 juil. 2016

publication

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models

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27 mai 2016

publication

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

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05 févr. 2016

publication

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

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28 janv. 2016

publication

[Relationships between venomous function and innate immune function]

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21 sept. 2014

team

Signalisation et dynamique des récepteurs

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27 août 2013

publication

Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

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07 juin 2012

publication

Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from Viperidae venom

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01 déc. 2011

publication

Structural and Functional Characterization of Anticoagulant, FXa-binding Viperidae Snake Venom Phospholipases A2

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28 oct. 2011

publication

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

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23 juil. 2011

publication

Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric β-neurotoxin

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24 mai 2010

publication

Functional and immunological characterization of the var2CSA-DBL5epsilon domain of a placental Plasmodium falciparum isolate

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22 oct. 2009

publication

Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells

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06 déc. 2007

publication

Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics

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26 oct. 2007

publication

The first phospholipase inhibitor from the serum of Vipera ammodytes ammodytes

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16 déc. 2006

publication

Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation

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07 nov. 2006

publication

Receptor-binding studies of the DBLgamma domain of Plasmodium falciparum erythrocyte membrane protein 1 from a placental isolate

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17 janv. 2006

publication

Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity

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07 juil. 2005

publication

The C-terminal and beta-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect

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10 nov. 2003

publication

Fcgamma receptor-like activity of hepatitis C virus core protein

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21 mars 2003

publication

The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoforms

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01 mars 2003

publication

Crotoxin acceptor protein isolated from Torpedo electric organ: binding properties to crotoxin by surface plasmon resonance

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06 févr. 2003

publication

Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin

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15 févr. 2002

publication

Inhibition of crotoxin phospholipase A(2) activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex

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Un petit guide pour l'utilisation de la recherche avancée :

Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.

25th Meeting (RT25) of the French Society of Toxinology (SFET) : “Toxins and Health: from Molecules to Organisms”.

Rattlesnake Phospholipase A2 increases CFTR-chloride channel current and corrects DF508CFTR dysfunction providing scaffold for chemical synthesis of dual modulators correctiong DF508CFTR ; application to treatment of Cystic Fibrosis

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors

Neuroscience – unité Récepteurs-Canaux Lab Seminar

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

[Relationships between venomous function and innate immune function]

Signalisation et dynamique des récepteurs

Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from Viperidae venom

Structural and Functional Characterization of Anticoagulant, FXa-binding Viperidae Snake Venom Phospholipases A2

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric β-neurotoxin

Functional and immunological characterization of the var2CSA-DBL5epsilon domain of a placental Plasmodium falciparum isolate

Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells

Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics

The first phospholipase inhibitor from the serum of Vipera ammodytes ammodytes

Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation

Receptor-binding studies of the DBLgamma domain of Plasmodium falciparum erythrocyte membrane protein 1 from a placental isolate

Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity

The C-terminal and beta-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect

Fcgamma receptor-like activity of hepatitis C virus core protein

The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoforms

Crotoxin acceptor protein isolated from Torpedo electric organ: binding properties to crotoxin by surface plasmon resonance

Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin

Inhibition of crotoxin phospholipase A(2) activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex