SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53

Lien vers Pubmed [PMID] – 20975832

PLoS ONE 2010;5(10):e13502

The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.