Lien vers Pubmed [PMID] – 22257484
Lien DOI – 10.3201/eid1801.110556
Emerg Infect Dis 2012 Jan; 18(1): 86-90
We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.