Lien vers Pubmed [PMID] – 26525799
Antimicrob. Agents Chemother. 2015 Nov;
Treatment of Candida glabrata cystitis remains a therapeutic challenge and antifungal combination using flucytosine is one option. We describe 2 patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapid acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.