• 2025
  Mathilde Briday, Nicolas Carvalho, Natalia Oganesyan, Min-Ju Chang, Andrew Lees, Sébastien Brier, Alexandre Chenal, Comparative analysis of the structural dynamics of diphtheria toxin and CRM197 carrier proteins used in the development of conjugate vaccines, International Journal of Pharmaceutics, 2025, 675, pp.125535. ⟨10.1016/j.ijpharm.2025.125535⟩.
• 2023
  Dazzoni R, Li Y, López-Castilla A, Brier S, Mechaly A, Cordier F, Haouz A, Nilges M, Francetic O, Bardiaux B, Izadi-Pruneyre N, Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system., Structure 2023 Feb; 31(2): 152-165.e7.
• 2022
  Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A, , Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
• 2022
  Gransagne M, Aymé G, Brier S, Chauveau-Le Friec G, Meriaux V, Nowakowski M, Dejardin F, Levallois S, Dias de Melo G, Donati F, Prot M, Brûlé S, Raynal B, Bellalou J, Goncalves P, Montagutelli X, Di Santo JP, Lazarini F, England P, Petres S, Escriou N, Lafaye P, , Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein., J Biol Chem 2022 Jan; 298(1): 101290.
• 2021
  Brier S, Rasetti-Escargueil C, Wijkhuisen A, Simon S, Marechal M, Lemichez E, Popoff MR, , Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A., FASEB J 2021 May; 35(5): e21540.
• 2021
  Voegele A, Sadi M, O'Brien DP, Gehan P, Raoux-Barbot D, Davi M, Hoos S, Brûlé S, Raynal B, Weber P, Mechaly A, Haouz A, Rodriguez N, Vachette P, Durand D, Brier S, Ladant D, Chenal A, , A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells., Adv Sci (Weinh) 2021 05; 8(9): 2003630.
• 2020
  O'Brien DP, Hourdel V, Chenal A, Brier S, Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins., Methods Mol Biol 2020 ; 2127(): 339-358.
• 2019
  Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD, Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments, Nat. Methods 2019 07;16(7):595-602.
• 2019
  O'Brien DP, Cannella SE, Voegele A, Raoux-Barbot D, Davi M, Douché T, Matondo M, Brier S, Ladant D, Chenal A, , Post-translational acylation controls the folding and functions of the CyaA RTX toxin., FASEB J 2019 09; 33(9): 10065-10076.
• 2019
  Bardiaux B, Cordier F, Brier S, López-Castilla A, Izadi-Pruneyre N, Nilges M, Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches, J. Biomol. NMR 2019 Jul;73(6-7):293-303.
• 2018
  Voegele A, O'Brien DP, Subrini O, Sapay N, Cannella SE, Enguéné VYN, Hessel A, Karst J, Hourdel V, Perez ACS, Davi M, Veneziano R, Chopineau J, Vachette P, Durand D, Brier S, Ladant D, Chenal A, Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis., Pathog Dis 2018 Nov; 76(8): .
• 2017
  Brier S, Le Mignon M, Jain K, Lebrun C, Peurois F, Kellenberger C, Bordas-Le Floch V, Mascarell L, Nony E, Moingeon P, Characterization of epitope specificities of reference antibodies used for the quantification of the birch pollen allergen Bet v 1, Allergy 2017 Nov;.
• 2017
  Hamdi K, Salladini E, O'Brien DP, Brier S, Chenal A, Yacoubi I, Longhi S, Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins, Sci Rep 2017 Nov;7(1):15544.
• 2017
  Delhommel F, Cordier F, Bardiaux B, Bouvier G, Colcombet-Cazenave B, Brier S, Raynal B, Nouaille S, Bahloul A, Chamot-Rooke J, Nilges M, Petit C, Wolff N, Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure 2017 11;25(11):1645-1656.e5.
• 2017
  Guilvout I, Brier S, Chami M, Hourdel V, Francetic O, Pugsley AP, Chamot-Rooke J, Huysmans GH., Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD., J Biol Chem. 2017 Jan 6;292(1):328-338..
• 2017
  Canul-Tec JC, Assal R, Cirri E, Legrand P, Brier S, Chamot-Rooke J, Reyes N, Structure and allosteric inhibition of excitatory amino acid transporter 1, Nature 2017 04;544(7651):446-451.
• 2017
  Guilvout I, Brier S, Chami M, Hourdel V, Francetic O, Pugsley AP, Chamot-Rooke J, Huysmans GH, Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD., J Biol Chem 2017 Jan; 292(1): 328-338.
• 2017
  O'Brien DP, Durand D, Voegele A, Hourdel V, Davi M, Chamot-Rooke J, Vachette P, Brier S, Ladant D, Chenal A, Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis., PLoS Biol 2017 Dec; 15(12): e2004486.
• 2016
  Nony E, Le Mignon M, Brier S, Martelet A, Moingeon P, Proteomics for Allergy: from Proteins to the Patients, Curr Allergy Asthma Rep 2016 Sep;16(9):64.
• 2016
  Hourdel V, Volant S, O'Brien DP, Chenal A, Chamot-Rooke J, Dillies MA, Brier S, MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets., Bioinformatics 2016 Nov; 32(22): 3413-3419.
• 2016
  Liguori Alessia, Malito Enrico, Lo Surdo Paola, Fagnocchi Luca, Cantini Francesca, Haag F. Andreas, Brier Sébastien, Pizza Mariagrazia, Delany Isabel, Bottomley J. Matthew, Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA, PLoS Pathog. 2016 Apr 22;12(4).
• 2015
  O'Brien DP, Hernandez B, Durand D, Hourdel V, Sotomayor-Pérez AC, Vachette P, Ghomi M, Chamot-Rooke J, Ladant D, Brier S, Chenal A, Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion., Sci Rep 2015 Sep; 5(): 14223.
• 2015
  Donnarumma D, Golfieri G, Brier S, Castagnini M, Veggi D, Bottomley MJ, Delany I, Norais N, Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein, FASEB J. 2015 Jun;29(6):2260-7.
• 2013
  Faleri A, Santini L, Brier S, Pansegrau W, Lo Surdo P, Scarselli M, Buricchi F, Volpini G, Genovese A, van der Veen S, Lea S, Tang CM, Savino S, Pizza M, Finco O, Norais N, Masignani V, Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties, FASEB J. 2014 Apr;28(4):1644-53.
• 2013
  Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V, Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen, Proc. Natl. Acad. Sci. U.S.A. 2013 Feb;110(9):3304-9.
• 2012
  Fagnocchi L, Biolchi A, Ferlicca F, Boccadifuoco G, Brunelli B, Brier S, Norais N, Chiarot E, Bensi G, Kroll JS, Pizza M, Donnelly J, Giuliani MM, Delany I, Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine, Infect. Immun. 2013 Feb;81(2):560-9.
• 2012
  Brier S, Fagnocchi L, Donnarumma D, Scarselli M, Rappuoli R, Nissum M, Delany I, Norais N, Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid, Biochemistry 2012 Aug;51(34):6738-52.
• 2010
  Brier S, Pflieger D, Le Mignon M, Bally I, Gaboriaud C, Arlaud GJ, Daniel R, Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex, J. Biol. Chem. 2010 Oct;285(42):32251-63.
• 2009
  De Luca V, Maria G, De Mauro G, Catara G, Carginale V, Ruggiero G, Capasso A, Parisi E, Brier S, Engen JR, Capasso C, Aspartic proteinases in Antarctic fish, Mar Genomics 2009 Mar;2(1):1-10.
• 2008
  Brier, Sebastien, and John R. Engen, Hydrogen exchange mass spectrometry: principles and capabilities, Brier, S., & Engen, J. R. (2008). Hydrogen exchange mass spectrometry: principles and capabilities. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics. M. Chance, editor. Wiley, Hoboken, NJ, 11-43..
• 2007
  Brier S, Maria G, Carginale V, Capasso A, Wu Y, Taylor RM, Borotto NB, Capasso C, Engen JR, Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii, FEBS J. 2007 Dec;274(23):6152-66.
• 2007
  Chen S, Brier S, Smithgall TE, Engen JR, The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding, Protein Sci. 2007 Apr;16(4):572-81.
• 2006
  Brier S, Carletti E, DeBonis S, Hewat E, Lemaire D, Kozielski F, The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins, Biochemistry 2006 Dec;45(51):15644-53.
• 2006
  Brier S, Lemaire D, DeBonis S, Forest E, Kozielski F, Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents, J. Mol. Biol. 2006 Jul;360(2):360-76.
• 2006
  Brier S, Lemaire D, DeBonis S, Kozielski F, Forest E, Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5, Rapid Commun. Mass Spectrom. 2006;20(3):456-62.
• 2004
  Brier S, Lemaire D, Debonis S, Forest E, Kozielski F, Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5, Biochemistry 2004 Oct;43(41):13072-82.