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2024Multitrait analysis to decipher the intertwined genetic architecture of neuroanatomical phenotypes and psychiatric disorders., Biol Psychiatry Cogn Neurosci Neuroimaging 2024 Sep; (): .
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2024An approach to identify gene-environment interactions and reveal new biological insight in complex traits., Nat Commun 2024 Apr; 15(1): 3385.
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2022Fitting Gaussian mixture models on incomplete data, BMC Bioinformatics.
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2022Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort., Am J Hum Genet 2022 Jan; 109(1): 12-23.
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2021Mapping the human genetic architecture of COVID-19., Nature 2021 Dec; 600(7889): 472-477.
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2021Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes., Proc Natl Acad Sci U S A 2021 11; 118(47): .
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2021Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure., Mol Psychiatry 2021 Nov; 26(11): 6293-6304.
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2021Multitrait GWAS to connect disease variants and biological mechanisms., PLoS Genet 2021 Aug; 17(8): e1009713.
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2021Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women., Pharmacogenomics J 2021 08; 21(4): 446-457.
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2021Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank., Ophthalmology 2021 06; 128(6): 866-876.
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2021Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci., Mol Psychiatry 2021 06; 26(6): 2111-2125.
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2021Estimating the effective sample size in association studies of quantitative traits., G3 (Bethesda) 2021 Mar; (): .
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2021Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits., HGG Adv 2021 Jan; 2(1): .
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2020Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis., Proc Natl Acad Sci U S A 2020 12; 117(49): 31278-31289.
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2020Deriving stratified effects from joint models investigating gene-environment interactions., BMC Bioinformatics 2020 Jun; 21(1): 251.
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2020Mixed-model admixture mapping identifies smoking-dependent loci of lung function in African Americans., Eur J Hum Genet 2020 05; 28(5): 656-668.
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2020JASS: command line and web interface for the joint analysis of GWAS results., NAR Genom Bioinform 2020 Mar; 2(1): lqaa003.
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2020Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes, Nat. Genet. 2020 Jan;.
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2019Making the Most of Clumping and Thresholding for Polygenic Scores., Am J Hum Genet 2019 12; 105(6): 1213-1221.
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2019Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration., Nat Commun 2019 11; 10(1): 5121.
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2019RAISS: robust and accurate imputation from summary statistics., Bioinformatics 2019 11; 35(22): 4837-4839.
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2019A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context., Nat Commun 2019 10; 10(1): 4788.
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2019Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes., Am J Ophthalmol 2019 10; 206(): 245-255.
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2019A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals., Microbiome 2019 Sep; 7(1): 130.
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2019A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure., Hum Mol Genet 2019 08; 28(15): 2615-2633.
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2019Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions., Am J Epidemiol 2019 06; 188(6): 1033-1054.
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2019Efficient Implementation of Penalized Regression for Genetic Risk Prediction., Genetics 2019 05; 212(1): 65-74.
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2019Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids., Nat Genet 2019 04; 51(4): 636-648.
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2019Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives., Genetics 2019 Apr; 211(4): 1179-1189.
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2019Genetic effects on the commensal microbiota in inflammatory bowel disease patients., PLoS Genet 2019 03; 15(3): e1008018.
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2019Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies., Genetics 2019 02; 211(2): 483-494.
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2019Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity., Nat Commun 2019 01; 10(1): 376.
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2018Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation., Genome Biol 2018 12; 19(1): 222.
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2018VarExp: estimating variance explained by genome-wide GxE summary statistics., Bioinformatics 2018 10; 34(19): 3412-3414.
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2018Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr., Bioinformatics 2018 08; 34(16): 2781-2787.
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2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines., Genome Med 2018 Jul; 10(1): 59.
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2018A test for gene-environment interaction in the presence of measurement error in the environmental variable., Genet Epidemiol 2018 04; 42(3): 250-264.
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2018A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure., Am J Hum Genet 2018 03; 102(3): 375-400.
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2018lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals., BMC Bioinformatics 2018 02; 19(1): 68.
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2018An ancestry-based approach for detecting interactions., Genet Epidemiol 2018 02; 42(1): 49-63.
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2018Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets., Invest Ophthalmol Vis Sci 2018 02; 59(2): 629-636.
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2018Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels., Nat Commun 2018 01; 9(1): 260.
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2018Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges., Proc Natl Acad Sci U S A 2018 Jan; 115(3): E488-E497.
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2018Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries., PLoS One 2018 ; 13(6): e0198166.
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2017Covariate selection for association screening in multiphenotype genetic studies., Nat Genet 2017 Dec; 49(12): 1789-1795.
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2017Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis., Eur J Hum Genet 2017 11; 25(11): 1261-1267.
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2017Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases., Am J Epidemiol 2017 Oct; 186(7): 753-761.
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2017Update on the State of the Science for Analytical Methods for Gene-Environment Interactions., Am J Epidemiol 2017 Oct; 186(7): 762-770.
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2017Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions., Am J Epidemiol 2017 Oct; 186(7): 771-777.
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2017Fungal microbiota dysbiosis in IBD., Gut 2017 06; 66(6): 1039-1048.
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2017Evidence for large-scale gene-by-smoking interaction effects on pulmonary function., Int J Epidemiol 2017 06; 46(3): 894-904.
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2017Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women., Am J Respir Cell Mol Biol 2017 03; 56(3): 332-341.
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2017Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample., Menopause 2017 02; 24(2): 150-156.
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2017Screening for interaction effects in gene expression data., PLoS One 2017 ; 12(3): e0173847.
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2017A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts., PLoS One 2017 ; 12(3): e0173997.
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2016Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms., Cancer Res 2016 12; 76(24): 7160-7167.
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2016A perspective on interaction effects in genetic association studies., Genet Epidemiol 2016 Dec; 40(8): 678-688.
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2016Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits., Aging Cell 2016 Oct; 15(5): 811-24.
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2016Genomics, Telomere Length, Epigenetics, and Metabolomics in the Nurses’ Health Studies., Am J Public Health 2016 Sep; 106(9): 1663-8.
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2016An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group., Genet Epidemiol 2016 07; 40(5): 404-15.
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2016Power Calculation of Multi-step Combined Principal Components with Applications to Genetic Association Studies, Sci Rep 2016 05;6:26243.
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2016Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans., Mol Biol Evol 2016 Apr; 33(4): 898-914.
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2016Response to Day et al., Am J Hum Genet 2016 Feb; 98(2): 394-5.
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2016Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma., Nat Genet 2016 Feb; 48(2): 189-94.
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2015Leveraging local ancestry to detect gene-gene interactions in genome-wide data., BMC Genet 2015 Oct; 16(): 124.
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2015[Genetic and environmental factors of asthma and allergy: Results of the EGEA study]., Rev Mal Respir 2015 Oct; 32(8): 822-40.
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2015Fitness cost of antibiotic susceptibility during bacterial infection., Sci Transl Med 2015 Jul; 7(297): 297ra114.
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2015Finding the missing gene-environment interactions., Eur J Epidemiol 2015 May; 30(5): 353-5.
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2015Adjusting for heritable covariates can bias effect estimates in genome-wide association studies., Am J Hum Genet 2015 Feb; 96(2): 329-39.
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2015Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age., Epidemiology 2015 Jan; 26(1): 51-8.
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2014Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies., Am J Hum Genet 2014 May; 94(5): 662-76.
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2013Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing., Proc Natl Acad Sci U S A 2013 Dec; 110(51): 20747-52.
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2013Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study., Endocr Relat Cancer 2013 Dec; 20(6): 875-87.
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2013A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes., Genet Epidemiol 2013 May; 37(4): 323-33.
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2013Transcriptional response of mucoid Pseudomonas aeruginosa to human respiratory mucus., mBio 2013 Jan; 3(6): e00410-12.
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2013A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries., PLoS Pathog 2013 ; 9(9): e1003582.
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2013Exploring genome-wide – dietary heme iron intake interactions and the risk of type 2 diabetes., Front Genet 2013 ; 4(): 7.
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2012Challenges and opportunities in genome-wide environmental interaction (GWEI) studies., Hum Genet 2012 Oct; 131(10): 1591-613.
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2012Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases., Am J Hum Genet 2012 Jun; 90(6): 962-72.
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2012Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function., PLoS Genet 2012 ; 8(12): e1003098.
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2011Combining effects from rare and common genetic variants in an exome-wide association study of sequence data., BMC Proc 2011 Nov; 5 Suppl 9(): S44.
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2011Inflated type I error rates when using aggregation methods to analyze rare variants in the 1000 Genomes Project exon sequencing data in unrelated individuals: summary results from Group 7 at Genetic Analysis Workshop 17, Genet. Epidemiol. 2011;35 Suppl 1:S56-60.
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201017q21 variants modify the association between early respiratory infections and asthma., Eur Respir J 2010 Jul; 36(1): 57-64.
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2010Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects., Hum Hered 2010 ; 70(4): 292-300.
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2009Sex-specific effect of IL9 polymorphisms on lung function and polysensitization., Genes Immun 2009 Sep; 10(6): 559-65.
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2008Effect of 17q21 variants and smoking exposure in early-onset asthma., N Engl J Med 2008 Nov; 359(19): 1985-94.
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2007A two-step multiple-marker strategy for genome-wide association studies., BMC Proc 2007 ; 1 Suppl 1(): S134.
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2007Multistage designs in the genomic era: providing balance in complex disease studies., Genet Epidemiol 2007 ; 31 Suppl 1(): S118-23.