Developing a new experimental model to differentiate early from late forms of Alzheimer’s disease
The objective of the project is to develop an experimental model based on the use of induced pluripotent stem cells of human origin, to reproduce the aging and degeneration of neurons using specific identified factors and to reproduce the main markers of Alzheimer’s disease, in its two forms: sporadic late-onset and familial early-onset.
Mimicking the state of these neurons in an environment as close as possible to their natural environment, after transplantation into the brain in mice should help deciphering the early cellular and molecular events of the two early forms of the disease, in order to ultimately identify specific drug targets for treatment upstream of the appearance of clinical signs in patients.