FURTHEST: Unraveling the Foamy Virus interactions with the host: insights into the molecular mechanisms of entry and neutralization
The FURTHEST proposal concerns a multidisciplinary study that focuses on simian foamy viruses (SFVs) which are the most ancient retroviruses. SFVs are prevalent in non-human primates and are transmitted to humans via contact with […]
MIND Metabolism Immunity NeuroDevelopement
The ANRS 12225 – PEDIACAM III study involves a cohort of young adolescents infected with HIV placed early (median: 4 months) on antiretroviral therapy (ART) and not infected with HIV monitored in Cameroon. This […]
PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses
General context : Foamy viruses (FV) are the oldest retroviruses, described as largely nonpathogenic in their natural animal hosts. Simian foamy viruses (SFVs) can be transmitted to humans, where they establish persistent infection akin […]
The ANRS 12225-Pediacam study is coordinated by Mr. Tejiokem at the Center Pasteur in Cameroon. Since 2007, the project has included children exposed or infected with HIV-1 and a group of unexposed and uninfected […]
ANRS-EP38-IMMIP : Immune status after long term HIV infection in the perinatal period
Perinatal HIV infection – ANRS-EP38-IMMIP Potent combined antiretroviral therapy has transformed HIV disease into a stable chronic condition. Infected children born at the beginning of the epidemic are now reaching adulthood. The unique characteristics […]
PTR 437: Human infection by zoonotic foamy retroviruses: physiological and immunological factors involved in the restriction of viral emergence
A large proportion of the emerging viral pathogens that have affected humans in the last decades are purported to have originated from various animal species. Human infection by simian foamy viruses (SFVs) is a […]
REEMFOAMY : Human infection with zoonotic simian foamy retroviruses: role of virological and immunological factors in restricting viral emergence
The public health relevance of retroviruses of zoonotic origin is illustrated by the human immunodeficiency virus (HIV) epidemic, the worldwide distribution of human T-lymphotropic viruses (HTLVs), and the morbidity and mortality associated with both […]
Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)
A collaborative study with members of Pasteur Institute (A. Saez-Cirion, D. Scott-Algara), french perinatal cohort (ANRS CO10; J. Warszawsky) and 10 hospitals from Paris Area (Principal investigator, P. Frange). The study has included 76 […]
2023Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus., PLoS Pathog 2023 Apr; 19(4): e1011339.
2022Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells., PLoS Pathog 2022 May; 18(5): e1010470.
2021Impact of Early Versus Late Antiretroviral Treatment Initiation on Naive T Lymphocytes in HIV-1-Infected Children and Adolescents – The-ANRS-EP59-CLEAC Study., Front Immunol 2021 ; 12(): 662894.
2014Naive T lymphocytes and recent thymic emigrants are associated with HIV-1 disease history in french adolescents and young adults infected in the perinatal period: the ANRS-EP38-IMMIP study, Clin. Infect. Dis. 2014 Feb;58(4):573-87.
2012Relationships between HIV disease history and blood HIV-1 DNA load in perinatally infected adolescents and young adults: the ANRS-EP38-IMMIP study, J. Infect. Dis. 2012 May;205(10):1520-8.