Projets Projet En cours 2 Membres Development of inhibitors targeting the allosteric activation of adenyl cyclases Thérèse Malliavin (PI) We propose to develop a new strategy to inhibit bacterial adenyl cyclase toxins essential to the pathogenicity of several bacteria, by specifically targeting their allosteric activation. For this purpose, the analysis of the family […]
Anciennes Équipes Bioinformatique structurale Plate-Forme Technologique Production et Purification de Protéines Recombinantes
Publications Télécharger 2022 Davi M, Sadi M, Pitard I, Chenal A, Ladant D, , A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins., Toxins (Basel) 2022 Oct; 14(10): . 2022 Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A, , Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
