(EN) Foamy virus Env protein – where virus meets the cells and host immune system
PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses
General context : Foamy viruses (FV) are the oldest retroviruses, described as largely nonpathogenic in their natural animal hosts. Simian foamy viruses (SFVs) can be transmitted to humans, where they establish persistent infection akin […]
ANRS-EP59-CLEAC-II: Early initiation of antiretroviral therapy in children infected with HIV-1 in the perinatal period: impact on T lymphocyte function, immune activation and integrated HIV-1 DNA
Early initiation of antiretroviral therapy in children infected with HIV-1 in the perinatal period: impact on T lymphocyte function, immune activation and integrated HIV-1 DNA
The ANRS 12225-Pediacam study is coordinated by Mr. Tejiokem at the Center Pasteur in Cameroon. Since 2007, the project has included children exposed or infected with HIV-1 and a group of unexposed and uninfected […]
ANRS-EP38-IMMIP : Immune status after long term HIV infection in the perinatal period
Perinatal HIV infection – ANRS-EP38-IMMIP Potent combined antiretroviral therapy has transformed HIV disease into a stable chronic condition. Infected children born at the beginning of the epidemic are now reaching adulthood. The unique characteristics […]
PTR 437: Human infection by zoonotic foamy retroviruses: physiological and immunological factors involved in the restriction of viral emergence
A large proportion of the emerging viral pathogens that have affected humans in the last decades are purported to have originated from various animal species. Human infection by simian foamy viruses (SFVs) is a […]
REEMFOAMY : Human infection with zoonotic simian foamy retroviruses: role of virological and immunological factors in restricting viral emergence
The public health relevance of retroviruses of zoonotic origin is illustrated by the human immunodeficiency virus (HIV) epidemic, the worldwide distribution of human T-lymphotropic viruses (HTLVs), and the morbidity and mortality associated with both […]
Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)
A collaborative study with members of Pasteur Institute (A. Saez-Cirion, D. Scott-Algara), french perinatal cohort (ANRS CO10; J. Warszawsky) and 10 hospitals from Paris Area (Principal investigator, P. Frange). The study has included 76 […]
2023The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells., Nat Commun 2023 Mar; 14(1): 1262.
2022Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells., PLoS Pathog 2022 May; 18(5): e1010470.
2021Impact of Early Versus Late Antiretroviral Treatment Initiation on Naive T Lymphocytes in HIV-1-Infected Children and Adolescents – The-ANRS-EP59-CLEAC Study., Front Immunol 2021 ; 12(): 662894.
2019Case-control study of the immune status of humans infected with zoonotic gorilla simian foamy viruses, J. Infect. Dis. 2019 Dec;.
2019Inhibitors of the interferon response increase the replication of gorilla simian foamy viruses, Virology 2019 Dec;541:25-31.
2019An Immunodominant and Conserved B-Cell Epitope in the Envelope of Simian Foamy Virus Recognized by Humans Infected with Zoonotic Strains from Apes, J. Virol. 2019 Jun;93(11).
2019[Zoonotic foamy viruses : first medical study of infected people], Med Sci (Paris) 2019 Apr;35(4):298-301.
2019Twelfth International Foamy Virus Conference-Meeting Report, Viruses 2019 02;11(2).
2019Zoonotic infection with simian foamy viruses: potent neutralizing antibodies, Virologie (Montrouge) 2019 Feb;23(1):35-39.
2018Potent neutralizing antibodies in humans infected with zoonotic simian foamy viruses target conserved epitopes located in the dimorphic domain of the surface envelope protein, PLoS Pathog. 2018 Oct;14(10):e1007293.
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