A post-doc position is available at Institut Pasteur, Paris, in the lab of M. Ricchetti to study the
molecular mechanisms underlying a progeroid disease, Cockayne syndrome, and their link with regular ageing. A particular attention is given to ageing-related degenerative processes using patient-derived iPSCs and cerebral organoids as a model. The investigation may include – omics analyses, the role of mitochondrial dysfunction and oxidative stress in accelerated as well as physiological ageing. Most studies are done with patient-derived material. A novel mouse model is also used.
Our study is based on a novel and experimentally supported hypothesis linking transcriptional
changes, largely resulting from epigenomic regulation, in turn depending on the management of oxidative and nitrosative stress, as triggers of ageing-related degenerative processes. These studies have implication for therapeutic perspectives. We also aim to discover and functionally validate novel genes involved in the ageing process.
Experience in ageing-related studies is strongly recommended. The candidate should have an
experimental background in at least one of the following fields: iPSCs and cerebral organoids
cultures, cellular biology, confocal microscopy, omics analysis (DNA methylation and RNAseq),
CRISPR/Cas9 technology.
Large intellectual autonomy and experimental excellence are required.
Funds are available for one year, with possibility of prolongation.
The position is available immediately.
Send motivation letter, CV with list of publications, and reference letters to
miria.ricchetti@pasteur.fr
Chatre et al, 2015, Proc. Natl, Acad Sci USA, PMID: 26038566
Crochemore et al, 2019, Nature Communications, PMID: 31811121
Crochemore et al, 2022, Antioxidt Redox Signal, PMID: 34428933
Crochemore et al, 2023, Aging Cell, in press
Miria Ricchetti, Ph.D.
Molecular Mechanisms of Pathological and Physiological Ageing
Dept. of Developmental & Stem Cell Biology, Institut Pasteur
CNRS UMR3738
25 rue du Dr. Roux, 75015, Paris, France
Office: +33 (1) 4568 8567; miria.ricchetti@pasteur.fr