Development of inhibitors targeting the allosteric activation of adenyl cyclases

Présentation

We propose to develop a new strategy to inhibit bacterial adenyl cyclase toxins essential to the pathogenicity of several bacteria, by specifically targeting their allosteric activation. For this purpose, the analysis of the family of thiophene ureoacid compounds, adenyl cyclase inhibitors, will be intensified by X-ray crystallography, bioinformatics, and cell biology approaches in order to select high affinity inhibitors capable of blocking in vivo the action of these toxins.