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© Research
Project

Development of inhibitors targeting the allosteric activation of adenyl cyclases

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
04
Oct 2017
Ending Date
30
Sep 2020
Status
Ongoing
Members
2
Structures
1

About

We propose to develop a new strategy to inhibit bacterial adenyl cyclase toxins essential to the pathogenicity of several bacteria, by specifically targeting their allosteric activation. For this purpose, the analysis of the family of thiophene ureoacid compounds, adenyl cyclase inhibitors, will be intensified by X-ray crystallography, bioinformatics, and cell biology approaches in order to select high affinity inhibitors capable of blocking in vivo the action of these toxins.