Présentation
We found that RoRgt expressing innate lymphoid cells (ILC) develop in the fetal liver but not in the bone marrow (BM). However, BM progenitors give rise to RoRgt+ILC in the peripheral lymphoid organs and that this differentiation depends on the activation of the Notch signaling pathway. Therefore, fetal and adult environments influence the differentiation of RORgt+ cells differently (Possot et al 2011, Nat Immunol). We are currently analyzing the role of the Notch signaling pathway in the development and functional maturation of the different subsets of ILC, in fetal and adult life by the characterization of IL-7Ra-Cre mouse line crossed to different mutant strains that allow conditional deletion or over-expression of different proteins involved in this signaling pathway.
