Link to Pubmed [PMID] – 29376946
J Fungi (Basel) 2016 Nov;2(4)
The global mortality due to cryptococcosis caused by or is unacceptably high. Currently available therapies are decades old and may be impacted by drug resistance. Therefore, the need for more effective antifungal drugs for cryptococcosis is evident. A number of virulence factors have been studied in detail, providing crucial information about the fungal biology and putative molecular targets for antifungals. This review focuses on the use of well-described virulence factors of as potential anticryptococcal agents.