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© Research
Publication : Proceedings. Biological sciences / The Royal Society

Vaccination, evolution and changes in the efficacy of vaccines: a theoretical framework

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings. Biological sciences / The Royal Society - 22 Sep 1995

McLean AR

Link to Pubmed [PMID] – 8587880

Proc. Biol. Sci. 1995 Sep;261(1362):389-93

The evolution of vaccine-resistant strains of infectious agents is potentially a huge problem for their control by immunization. Yet, for many infectious diseases, it has been possible to drive them to the verge of extinction without vaccine escape mutants arising. This paper establishes a theoretical framework within which to ask why this should be so, what properties of vaccines allow this situation and what might happen in situations where vaccine escape mutants do arise.

http://www.ncbi.nlm.nih.gov/pubmed/8587880