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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : Comparative immunology, microbiology and infectious diseases

Use of camel single-domain antibodies for the diagnosis and treatment of zoonotic diseases.

Team: Antibody Engineering
Member: Pierre Lafaye
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comparative immunology, microbiology and infectious diseases - 01 Oct 2018

Lafaye P, Li T,

Link to Pubmed [PMID] – 30396425

Link to DOI – S0147-9571(18)30072-910.1016/j.cimid.2018.09.009

Comp Immunol Microbiol Infect Dis 2018 Oct; 60(): 17-22

Camelids produce both conventional heterotetrameric antibodies and homodimeric heavy-chain only antibodies. The antigen-binding region of such homodimeric heavy-chain only antibodies consists of one single domain, called VHH. VHHs provide many advantages over conventional full-sized antibodies and currently used antibody-based fragments (Fab, scFv), including high specificity, stability and solubility, and small size, allowing them to recognize unusual antigenic sites and deeply penetrate tissues. Since their discovery, VHHs have been used extensively in diagnostics and therapy. In recent decades, the number of outbreaks of diseases transmissible from animals to humans has been on the rise. In this review, we evaluate the status of VHHs as diagnostic and therapeutic biomolecular agents for the detection and treatment of zoonotic diseases, such as bacterial, parasitic, and viral zoonosis. VHHs show great adaptability to inhibit or neutralize pathogenic agents for the creation of multifunctional VHH-based diagnostic and therapeutic molecules against zoonotic diseases.