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© Research
Publication : Scientific reports

Tupanvirus-infected amoebas are induced to aggregate with uninfected cells promoting viral dissemination.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scientific reports - 17 Jan 2019

Oliveira G, Silva L, Leão T, Mougari S, da Fonseca FG, Kroon EG, La Scola B, Abrahão JS,

Link to Pubmed [PMID] – 30655573

Link to DOI – 10.1038/s41598-018-36552-4

Sci Rep 2019 01; 9(1): 183

The discovery of giant viruses in the last years has fascinated the scientific community due to virus particles size and genome complexity. Among such fantastic discoveries, we have recently described tupanviruses, which particles present a long tail, and has a genome that contains the most complete set of translation-related genes ever reported in the known virosphere. Here we describe a new kind of virus-host interaction involving tupanvirus. We observed that tupanvirus-infected amoebas were induced to aggregate with uninfected cells, promoting viral dissemination and forming giant host cell bunches. Even after mechanical breakdown of bunches, amoebas reaggregated within a few minutes. This remarkable interaction between infected and uninfected cells seems to be promoted by the expression of a mannose receptor gene. Our investigations demonstrate that the pre-treatment of amoebas with free mannose inhibits the formation of bunches, in a concentration-dependent manner, suggesting that amoebal-bunch formation correlates with mannose receptor gene expression. Finally, our data suggest that bunch-forming cells are able to interact with uninfected cells promoting the dissemination and increase of tupanvirus progeny.