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© Research
Publication : Research in microbiology

Trinucleotide repeats and other microsatellites in yeasts

Team: Spatial Regulation of Genomes
Member: Agnès Thierry
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in microbiology - 01 Nov 1999

Richard GF, Hennequin C, Thierry A, Dujon B

Link to Pubmed [PMID] – 10672999

Res. Microbiol. 1999 Nov-Dec;150(9-10):589-602

Microsatellites are direct tandem DNA repeats found in all genomes. A particular class of microsatellites, called trinucleotide repeats, is responsible for a number of neurological disorders in humans. We review here our current state of knowledge on trinucleotide repeat instability, and discuss the molecular mechanisms that may be involved in trinucleotide repeat expansions leading to fatal diseases in humans. We also present original data on microsatellite distribution in several microbial genomes, and on the use of microsatellites as physical markers to accurately and easily genotype yeast strains.