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© Research
Publication : Journal of hepatology

Treatment of hepatitis C virus in human immunodeficiency virus infected patients in “real life”: modifications in two large surveys between 2004 and 2006

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of hepatology - 02 Oct 2007

Cacoub P, Halfon P, Rosenthal E, Pialoux G, Benhamou Y, Perronne C, Pol S,

Link to Pubmed [PMID] – 17945375

J. Hepatol. 2008 Jan;48(1):35-42

BACKGROUND/AIMS: To analyze the barriers to HCV treatment in HIV-HCV co-infected patients and their evolution between 2004 and 2006.

METHODS: Three hundred and eighty HIV-HCV co-infected patients were prospectively included in surveys from November 22 to 29, 2004 (2004 survey), and 416 from April 3 to 10, 2006 (2006 survey).

RESULTS: Patients in 2006 compared to those in 2004 had negative HCV RNA more often (24% vs. 12%). The rate of liver biopsy was similar (56% vs. 54%) while 24% had had a non-invasive liver damage assessment. The rate of previous treatment for HCV infection was higher (48% vs. 26%). The main reasons for HCV non-treatment have changed: HCV treatment deemed questionable (44% vs. 53%), lack of liver biopsy (18% vs. 33%), physicians’ conviction of poor patient compliance (20% vs. 30%). In both surveys, HCV treated patients were more often of European origin, had better control of HIV infection, and had a liver damage assessment more often.

CONCLUSIONS: The care of HIV-HCV co-infected patients has changed significantly in “real life”. These results underline the importance of continuing efforts to educate physicians and patients in order to increase the access of co-infected patients to HCV treatment.

https://www.ncbi.nlm.nih.gov/pubmed/17945375