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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Transplantation tolerance is unrelated to superantigen-dependent deletion and anergy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 01 Nov 1992

Salaün J, Bandeira A, Khazaal I, Burlen-Defranoux O, Thomas-Vaslin V, Coltey M, Le Douarin NM, Coutinho A

Link to Pubmed [PMID] – 1438228

Proc. Natl. Acad. Sci. U.S.A. 1992 Nov;89(21):10420-4

C57BL/6 (B6; I-E-, Mls-2b) nude mice, reconstituted at birth with thymic epithelium (TE) from BALB/c (BA; I-E+, Mls-2a) day 10 embryos (E10), permanently accepted BALB/c skin, when grafted as adults. T-cell receptor repertoire analyses in the periphery of these mice revealed no difference in frequencies of I-E/superantigen-reactive T-cell receptor V beta families, as compared to chimeras constructed with syngeneic B6 E10 TE. T lymphocytes bearing V beta 3, V beta 5, and V beta 11 T-cell receptors, from either allogeneic or syngeneic TE chimeras, responded equally well to in vitro receptor-dependent stimulation. Similar results were obtained with nude mice reconstituted at birth with E14 thymuses, already colonized by hemopoietic cells. These observations indicate that neither TE cells nor the progenies of hemopoietic precursors that colonize the thymus up to E14 express or functionally present the superantigens addressed here; it follows that tolerance to skin grafts and superantigen-related T-cell deletions are unrelated phenomena.

http://www.ncbi.nlm.nih.gov/pubmed/1438228