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© Research
Publication : The American journal of tropical medicine and hygiene

Transmission intensity and Plasmodium falciparum diversity on the northwestern border of Thailand

Team: Archived: Infectious Reservoir of Vector-borne Diseases
Member: Richard Paul
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The American journal of tropical medicine and hygiene - 01 Feb 1998

Paul RE, Hackford I, Brockman A, Muller-Graf C, Price R, Luxemburger C, White NJ, Nosten F, Day KP

Link to Pubmed [PMID] – 9502604

Am. J. Trop. Med. Hyg. 1998 Feb;58(2):195-203

Genetic analysis of the number of Plasmodium falciparum genotypes per infected person in regions of holoendemic and hyperendemic malaria suggest that in areas of lower transmission intensity, significantly fewer parasite genotypes per infected person should be found. A predominance of single clone infections in the human population could generate the controversial clonal population structure proposed for P. falciparum by Tibayrenc and others. Characterization of P. falciparum from individuals on the Thai-Burmese border, an area of hypoendemic transmission, revealed a higher number of genotypes per infected person than that predicted. Possible reasons for this observation are discussed, with particular attention paid to human migration and multidrug resistance.