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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Stem cell reports

Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Stem cell reports - 21 Jun 2017

Freire AG, Waghray A, Soares-da-Silva F, Resende TP, Lee DF, Pereira CF, Nascimento DS, Lemischka IR, Pinto-do-Ó P

Link to Pubmed [PMID] – 28648899

Stem Cell Reports 2017 Jun;

Notch signaling plays a role in specifying a cardiac fate but the downstream effectors remain unknown. In this study we implicate the Notch downstream effector HES5 in cardiogenesis. We show transient Hes5 expression in early mesoderm of gastrulating embryos and demonstrate, by loss and gain-of-function experiments in mouse embryonic stem cells, that HES5 favors cardiac over primitive erythroid fate. Hes5 overexpression promotes upregulation of the cardiac gene Isl1, while the hematopoietic regulator Scl is downregulated. Moreover, whereas a pulse of Hes5 instructs cardiac commitment, sustained expression after lineage specification impairs progression of differentiation to contracting cardiomyocytes. These findings establish a role for HES5 in cardiogenesis and provide insights into the early cardiac molecular network.

https://www.ncbi.nlm.nih.gov/pubmed/28648899