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© Research
Publication : The Journal of experimental medicine

Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of experimental medicine - 18 Jan 1999

Agenès F, Freitas AA

Link to Pubmed [PMID] – 9892614

J. Exp. Med. 1999 Jan;189(2):319-30

We studied the role of bone marrow B cell production in the renewal of peripheral B cells and the feedback mechanisms that control the entry of newly formed B cells into the peripheral B cell pools. When resting lymph node B cells are injected into B cell-deficient hosts, a fraction of the transferred cells expands and constitutes a highly selected population that survives for prolonged periods of time by continuous cell renewal at the periphery. Although the number of donor B cells recovered is low, a significant fraction shows an activated phenotype, and the serum immunoglobulin (Ig)M levels are as in normal mice. This population of activated B cells is resistant to replacement by a new cohort of B cells and is able to feedback regulate both the entry of newly formed B cells into the peripheral pool and terminal differentiation. These findings suggest that peripheral B cell selection follows the first come, first served rule and that IgM-secreting cells are generated from a pool of stable activated B cells with an independent homeostasis.

http://www.ncbi.nlm.nih.gov/pubmed/9892614