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© Research
Publication : Genome biology

Transcriptome-wide modulation of splicing by the exon junction complex

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genome biology - 01 Jan 2014

Wang Z, Murigneux V, Le Hir H

Link to Pubmed [PMID] – 25476502

Genome Biol. 2014;15(12):551

The exon junction complex (EJC) is a dynamic multi-protein complex deposited onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins, eIF4A3, Magoh, Y14 and MLN51, are stably bound to mRNAs during their lifecycle, serving as a binding platform for other nuclear and cytoplasmic proteins. Recent evidence has shown that the EJC is involved in the splicing regulation of some specific events in both Drosophila and mammalian cells.

http://www.ncbi.nlm.nih.gov/pubmed/25476502