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© Research
Publication : Nature reviews. Genetics

Transcription factors: from enhancer binding to developmental control

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Genetics - 07 Aug 2012

Spitz F, Furlong EE

Link to Pubmed [PMID] – 22868264

Nat. Rev. Genet. 2012 Sep;13(9):613-26

Developmental progression is driven by specific spatiotemporal domains of gene expression, which give rise to stereotypically patterned embryos even in the presence of environmental and genetic variation. Views of how transcription factors regulate gene expression are changing owing to recent genome-wide studies of transcription factor binding and RNA expression. Such studies reveal patterns that, at first glance, seem to contrast with the robustness of the developmental processes they encode. Here, we review our current knowledge of transcription factor function from genomic and genetic studies and discuss how different strategies, including extensive cooperative regulation (both direct and indirect), progressive priming of regulatory elements, and the integration of activities from multiple enhancers, confer specificity and robustness to transcriptional regulation during development.

http://www.ncbi.nlm.nih.gov/pubmed/22868264