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© Research
Publication : European heart journal

Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience

Team: Group: Humanized mice and in vivo analysis of human Plasmodium infections
Team: Archived: Lymphocyte Population Biology
Member: Sylvie Garcia
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European heart journal - 16 May 2014

Menasché P, Vanneaux V, Fabreguettes JR, Bel A, Tosca L, Garcia S, Bellamy V, Farouz Y, Pouly J, Damour O, Périer MC, Desnos M, Hagège A, Agbulut O, Bruneval P, Tachdjian G, Trouvin JH, Larghero J

Link to Pubmed [PMID] – 24835485

Eur. Heart J. 2015 Mar;36(12):743-50

There is now compelling evidence that cells committed to a cardiac lineage are most effective for improving the function of infarcted hearts. This has been confirmed by our pre-clinical studies entailing transplantation of human embryonic stem cell (hESC)-derived cardiac progenitors in rat and non-human primate models of myocardial infarction. These data have paved the way for a translational programme aimed at a phase I clinical trial.