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  • Director of Center
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Scientific Fields
Diseases
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Published in Cell cycle (Georgetown, Tex.) - 01 Aug 2012

Kachaner D, Génin P, Laplantine E, Weil R

Link to Pubmed [PMID] – 22801549

Cell Cycle 2012 Aug;11(15):2808-18

This review highlights recent advances in our understanding of the mechanisms of Optineurin (Optn) action and its implication in diseases. Optn has emerged as a key player regulating various physiological processes, including membrane trafficking, protein secretion, cell division and host defense against pathogens. Furthermore, there is growing evidence for an association of Optn mutations with human diseases such as primary open-angle glaucoma, amyotrophic lateral sclerosis and Paget’s disease of bone. Optn functions depend on its precise subcellular localization and its interaction with other proteins. Here, we review the mechanisms that allow Optn to ensure a timely and spatially coordinated integration of different physiological processes and discuss how their deregulation may lead to different pathologies.

http://www.ncbi.nlm.nih.gov/pubmed/22801549