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© Charles Dauguet
Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.
Publication : Journal of virology

TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 07 Mar 2012

Valle-Casuso JC, Di Nunzio F, Yang Y, Reszka N, Lienlaf M, Arhel N, Perez P, Brass AL, Diaz-Griffero F

Link to Pubmed [PMID] – 22398280

J. Virol. 2012 May;86(10):5931-6

TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import.

http://www.ncbi.nlm.nih.gov/pubmed/22398280