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© Research
Publication : Journal of the Association for Research in Otolaryngology : JARO

Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of the Association for Research in Otolaryngology : JARO - 01 Jun 2008

Auer M, Koster AJ, Ziese U, Bajaj C, Volkmann N, Wang da N, Hudspeth AJ,

Link to Pubmed [PMID] – 18421501

Link to DOI – 10.1007/s10162-008-0114-2

J Assoc Res Otolaryngol 2008 Jun; 9(2): 215-24

The senses of hearing and balance rest upon mechanoelectrical transduction by the hair bundles of hair cells in the inner ear. Located at the apical cellular surface, each hair bundle comprises several tens of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. Using electron-microscopic tomography of bullfrog saccular sensory epithelia, we examined the three-dimensional structures of basal links, kinociliary links, and tip links. We observed significant differences in the appearances and dimensions of these three structures and found two distinct populations of tip links suggestive of the involvement of different proteins, splice variants, or protein-protein interactions. We noted auxiliary links connecting the upper portions of tip links to the taller stereocilia. Tip links and auxiliary links show a tendency to adopt a globular conformation when disconnected from the membrane surface.

https://pubmed.ncbi.nlm.nih.gov/18421501