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© Research
Publication : Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Therapeutic vaccination against chronic hepatitis B virus infection

Team: Archived: Pathogenesis of Hepatitis B Virus
Member: Marie-Louise Michel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 01 Dec 2005

Michel ML, Mancini-Bourgine M

Link to Pubmed [PMID] – 16461209

J. Clin. Virol. 2005 Dec;34 Suppl 1:S108-14

Chronic liver disease and hepatocellular carcinoma due to chronic hepatitis B virus (HBV) infection pose a major public health problem in highly endemic regions. Effective vaccines against HBV exist but more than 370 million people remain chronically infected with HBV For these patients there is a high risk to develop cirrhosis and hepatocellular carcinoma. Currently available therapies fail to control viral replication in the long term in most patients. Viral persistence has been associated with a defect in the development of HBV specific cellular immunity. Strategies to boost or to broaden the weak virus-specific T-cell response of patients with chronic hepatitis B have been proposed as a means of curing this persistent infection. HBV envelope- and nucleocapsid-based vaccines, new formulations for recombinant vaccines and DNA-based vaccines are currently being assessed in clinical trials. Improvements are clearly required, but vaccination is likely to be the cheapest and potentially most beneficial treatment.