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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Vaccine

The use of vaccine antigen characterization, for example by MATS, to guide the introduction of meningococcus B vaccines

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 30 May 2012

Vogel U, Stefanelli P, Vazquez J, Taha MK, Claus H, Donnelly J

Link to Pubmed [PMID] – 22607902

Vaccine 2012 May;30 Suppl 2:B73-7

Current concepts of vaccines against serogroup B meningococci (MenB) are mainly based on genetically variable protein antigens. Vaccine efficacy studies for meningococcal disease in developed countries are hampered by the low incidence. Licensure must therefore exclusively rely on clinical trials and laboratory investigation of meningococcal strains. In contrast to capsule polysaccharide vaccines, serum bactericidal assays for technical reasons are limited in their practicability as the surrogate of protection provided by MenB vaccines. Therefore, assays are required for reliable laboratory based assessment of expression of those specific antigen variants that are predicted to be targeted by bactericidal antibodies elicited by the vaccine. The MATS ELISA (MATS, meningococcal antigen typing system) reported recently is an example for such an assay. The paper discusses the pre- and post-licensure application of MATS, the role of reference laboratories, concepts of sustained provision of the assay, external quality assessment, and laboratory twinning.

https://www.ncbi.nlm.nih.gov/pubmed/22607902