Link to Pubmed [PMID] – 6335440
Dev. Biol. Stand. 1984;57:385-91
Eight syngeneic HP-id specific for anti-GAT antibodies are tested for their capacity to detect idiotypes on GAT-specific T cell lines. Their affinity constants are between 5 X 10(-7) and 10(-8) molar-1 which permit significant binding analysis. They detect idiotopes expressed in anti-GAT sera from all the strains of mice tested and by 14 BALB/c HP-GAT. In addition, the distribution of the corresponding idiotopes among all allogeneic HP-GAT allow the identification of two groups of idiotopes. Some idiotopes are expressed by a minority of HP-GAT; the other idiotopes are expressed by all of them. Nevertheless, in spite of the broad molecular and genetic distribution of these idiotopes on anti-GAT antibodies, they are not expressed by three GAT-specific T cell lines from different genetic origins.