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© Research
Publication : The European journal of neuroscience

The ubiquitin-proteasome cascade is required for mammalian long-term memory formation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The European journal of neuroscience - 01 Dec 2001

Lopez-Salon M, Alonso M, Vianna MR, Viola H, Mello e Souza T, Izquierdo I, Pasquini JM, Medina JH

Link to Pubmed [PMID] – 11860477

Eur. J. Neurosci. 2001 Dec;14(11):1820-6

It has been recently demonstrated that ubiquitin-proteasome-mediated proteolysis is required for long-term synaptic facilitation in Aplysia. Here we show that the hippocampal blockade of this proteolytic pathway is also required for the formation of long-term memory in the rat. Bilateral infusion of lactacystin, a specific proteasome inhibitor, to the CA1 region caused full retrograde amnesia for a one-trial inhibitory avoidance learning when given 1, 4 or 7h, but not 10 h, after training. Proteasome inhibitor I produced similar effects. In addition, inhibitory avoidance training resulted in an increased ubiquitination and 26S proteasome proteolytic activity and a decrease in the levels of IkappaB, a substrate of the ubiquitin-proteasome cascade, in hippocampus 4 h after training. Together, these findings indicate that the ubiquitin-proteasome cascade is crucial for the establishment of LTM in the behaving animal.

http://www.ncbi.nlm.nih.gov/pubmed/11860477