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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : FEBS letters

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 12 Feb 2010

Droll D, Archer S, Fenn K, Delhi P, Matthews K, Clayton C

Link to Pubmed [PMID] – 20153321

FEBS Lett. 2010 Mar;584(6):1156-62

Proteins with Pumilio RNA binding domains (Puf proteins) are ubiquitous in eukaryotes. Some Puf proteins bind to the 3′-untranslated regions of mRNAs, acting to repress translation and promote degradation; others are involved in ribosomal RNA maturation. The genome of Trypanosoma brucei encodes eleven Puf proteins whose function cannot be predicted by sequence analysis. We show here that epitope-tagged TbPUF7 is located in the nucleolus, and associated with a nuclear cyclophilin-like protein, TbNCP1. RNAi targeting PUF7 reduced trypanosome growth and inhibited two steps in ribosomal RNA processing.

http://www.ncbi.nlm.nih.gov/pubmed/20153321