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© Research
Publication : Developmental biology

The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo

Team: Dynamics of Developmental Decisions in Drosophila
Member: François Schweisguth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental biology - 01 Dec 1994

Schweisguth F, Nero P, Posakony JW

Link to Pubmed [PMID] – 7813798

Dev. Biol. 1994 Dec;166(2):812-4

Suppressor of Hairless [Su(H)] plays an essential role in neurogenesis in Drosophila by controlling successive alternative cell fate decisions in the developing adult epidermis. Analysis of the predicted amino acid sequence of the Su(H) protein revealed a weak similarity to the catalytic domain of a family of phage integrases and yeast recombinases. We present here the results of a site-directed mutagenesis of the integrase-related region of Su(H), which indicate that this sequence similarity has no functional significance in vivo. We suggest that the JK-RBP protein, encoded by the mouse homologue of Su(H), does not act as a recombinase, as originally proposed.