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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 01 Feb 1996

Ménard R, Prévost MC, Gounon P, Sansonetti P, Dehio C

Link to Pubmed [PMID] – 8577750

Proc. Natl. Acad. Sci. U.S.A. 1996 Feb;93(3):1254-8

The bacterial pathogen Shigella flexneri causes bacillary dysentery in humans by invading coloncytes. Upon contact with epithelial cells, S. flexneri elicits localized plasma membrane projections sustained by long actin filaments which engulf the microorganism. The products necessary for Shigella entry include three secretory proteins: IpaB, IpaC, and IpaD. Extracellular IpaB and IpaC associate in a soluble complex, the Ipa complex. We have immunopurified this Ipa complex on latex beads and found that they were efficiently internalized into HeLa cells. Like S. flexneri entry, uptake of the beads bearing the Ipa complex was associated with membrane projections and polymerization of actin at the site of cell-bead interaction and was dependent on small Rho GTPases. These results indicate that a secreted factor can promote S. flexneri entry into epithelial cells.

http://www.ncbi.nlm.nih.gov/pubmed/8577750