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© Research
Publication : Development (Cambridge, England)

The roles of receptor and ligand endocytosis in regulating Notch signaling

Team: Dynamics of Developmental Decisions in Drosophila
Member: François Schweisguth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Development (Cambridge, England) - 01 Apr 2005

Le Borgne R, Bardin A, Schweisguth F

Link to Pubmed [PMID] – 15790962

Development 2005 Apr;132(8):1751-62

Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.