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© Research
Publication : Infection and immunity

The putative glycosyltransferase-encoding gene cylJ and the group B Streptococcus (GBS)-specific gene cylK modulate hemolysin production and virulence of GBS

Team: Archived: Biology of Gram-Positive Pathogens
Team: Group: Shaynoor Dramsi
Team: Archived: Group : Patrick Trieu-Cuot
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 05 Feb 2007

Forquin MP, Tazi A, Rosa-Fraile M, Poyart C, Trieu-Cuot P, Dramsi S

Link to Pubmed [PMID] – 17283108

Infect. Immun. 2007 Apr;75(4):2063-6

Group B streptococcus (GBS) expresses a hemolysin/cytolysin that plays an important role in pathogenesis. Using the Himar1 transposon mutagenesis system, a hypohemolytic mutant carrying an interrupted cylJ gene was characterized. cylJ, encoding a putative glycosyltransferase, and cylK, whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS.