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© Research
Publication : Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society

The patchwork mouse phenotype: implication for melanocyte replacement in the hair follicle

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society - 01 Jun 1999

Aubin-Houzelstein G, Panthier JJ

Link to Pubmed [PMID] – 10385914

Pigment Cell Res. 1999 Jun;12(3):181-6

Mice homozygous for the recessive patchwork (pwk) mutation are characterized by a variegated pigment pattern with a mixture of unpigmented and normally pigmented hairs. The pigmented hair bulbs contain functional melanocytes. By contrast, the unpigmented hair bulbs contain no melanocytes. This lack results from the death of melanoblasts in the hair follicle at the end of embryogenesis. Here, we report that melanoblasts and melanocytes are found in the epidermis of pwk/pwk mice. Furthermore, these epidermal pigment cells are able to colonize new hair follicles after skin wounding. Despite the presence of epidermal pigment cells with a colonization potential, a follicle that had produced an unpigmented hair produces a new unpigmented hair during the successive hair growth cycles. This hair color continuity is also true for the pigmented hair follicles. Thus, in normal conditions, the hair acts as an independent functional unit as regards its pigment cells population.

http://www.ncbi.nlm.nih.gov/pubmed/10385914