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© Charles Dauguet
Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.
Publication : AIDS (London, England)

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

Team: Viral reservoirs and immune control
Team: Archived: Regulation of Retroviral Infections
Team: HIV, Inflammation and Persistence
Member: Asier Sáez-Cirión
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in AIDS (London, England) - 20 Feb 2014

Lissina A, Fastenackels S, Inglesias MC, Ladell K, McLaren JE, Briceño O, Gostick E, Papagno L, Autran B, Sauce D, Price DA, Saez-Cirion A, Appay V

Link to Pubmed [PMID] – 24384691

AIDS 2014 Feb;28(4):477-86

Although it is established that CD8 T-cell immunity is critical for the control of HIV replication in vivo, the key factors that determine antiviral efficacy are yet to be fully elucidated. Antigen-sensitivity and T-cell receptor (TCR) avidity have been identified as potential determinants of CD8⁺ T-cell efficacy. However, there is no general consensus in this regard because the relationship between these parameters and the control of HIV infection has been established primarily in the context of immunodominant CD8⁺ T-cell responses against the Gag₂₆₃₋₂₇₂ KK10 epitope restricted by human leukocyte antigen (HLA)-B27.