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© Research
Publication : PloS one

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways

Team: Archived: Group: Yu Wei
Team: Archived: Pathogenesis of Hepatitis B Virus
Member: Yu Wei
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 19 Nov 2008

Labalette C, Nouët Y, Levillayer F, Armengol C, Renard CA, Soubigou G, Xia T, Buendia MA, Wei Y

Link to Pubmed [PMID] – 19018287

PLoS ONE 2008;3(11):e3761

Four and a half LIM-only protein 2 (FHL2) has been implicated in multiple signaling pathways that regulate cell growth and tissue homeostasis. We reported previously that FHL2 regulates cyclin D1 expression and that immortalized FHL2-null mouse embryo fibroblasts (MEFs) display reduced levels of cyclin D1 and low proliferative activity.