My team has been working on signaling pathways, regulation of gene expression and hepatitis B virus in the control of cell proliferation, differentiation, death and transformation in the liver. The work of the team is focusing on how intricate molecular networks function through crosstalk and feedback links and how disruptions in cellular signaling lead to liver diseases and tumor development.
Molecular mechanisms regulating hepatitis B virus replication and liver carcinogenesis
Despite the existence of safe and efficient vaccines for more than twenty-five years, hepatitis B remains a public health problem of worldwide importance. It is currently estimated that 240 million people are chronic carriers […]
Born in Beijing, China
1994 Thesis in Virology (Ph.D.)
The University of Paris VII, Paris, France
2003 Ph. D. Thesis Supervisor (HDR)
The University of Paris V, Paris, France
RESEARCH POSITIONS :
Post-doc fellow, University of California, San Francisco (1994-1996)
Assistant, Institut Pasteur (1996-2000)
Chargé de recherche (2001-present)
2000, Mémain-Pelletier, Académie des Sciences, Institut de France
2016Single-nucleotide-resolution mapping of HBV promoters in infected human livers and hepatocellular carcinoma, J. Virol. 2016 Sep;.
2015Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress, Carcinogenesis 2016 Jan;37(1):39-48.
2013LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis., Mol Cell Biol 2013 Aug; 33(16): 3299-308.
2013The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b, Bone 2013 Mar;53(1):6-12.
2013The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia, J. Biol. Chem. 2013 Jan;288(3):1785-94.
2012The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis, J. Hepatol. 2012 Nov;57(5):1029-36.
2010Molecular biology of the hepatitis B virus and role of the X gene, Pathol. Biol. 2010 Aug;58(4):267-72.
2010Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice, PLoS ONE 2010;5(4):e10371.
2008Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer, Cancer Cell 2008 Dec;14(6):471-84.
2008The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways, PLoS ONE 2008;3(11):e3761.
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