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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : Virology journal

The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World

Team: Group: Pierre Emmanuel Ceccaldi
Team: Oncogenic Virus Epidemiology and Pathophysiology
Team: Archived: Innovation lab : vaccines
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virology journal - 18 Nov 2004

Lucas M, Frenkiel MP, Mashimo T, Guénet JL, Deubel V, Desprès P, Ceccaldi PE

Link to Pubmed [PMID] – 15550172

Virol. J. 2004;1:9

West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV strain IS-98-ST1 that has been isolated from a white stork in 1998, was found to be highly neuroinvasive in adult C57BL/6 mice. Strain IS-98-ST1 infects primary neuronal cells from mouse cortex, causing neuronal death. These results demonstrate that Israeli strain IS-98-ST1 provides a suitable viral model for WNV-induced disease associated with recent WNV outbreaks in the Old World.