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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Biomedical journal

The influence of space and time on the establishment of B cell identity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biomedical journal - 19 Sep 2019

Elsaid R, Yang J, Cumano A

Link to Pubmed [PMID] – 31627863

Biomed J 2019 08;42(4):209-217

During embryonic development multiple waves of hematopoietic progenitors with distinct lineage potential are differentially regulated in time and space. Consistent with this view, some specialized lymphocytes emerge during a limited time-window in embryogenesis and migrate to the tissues where they contribute to organogenesis and to tissue homeostasis. These cells are not constantly produced by bone marrow derived hematopoietic stem cells but are maintained in tissues and self-renew throughout life. These particular cell subsets are produced from lymphoid restricted progenitors only found in the first days of fetal liver hematopoietic activity. Growing evidence of the heterogeneity and layered organization of the hematopoietic system is leading to a common view that some lymphocyte subsets are functionally different because they follow distinct developmental programs and emerge from distinct waves of lymphoid progenitors. However, understanding the influence of developmental origin and the relative contribution of local microenvironment on the development of these specialized lymphocyte subsets needs further analysis. In this review, we discuss how different pathways followed by developing B cells during ontogeny may contribute to the diverse functions.

https://www.ncbi.nlm.nih.gov/pubmed/31627863