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© Research
Publication : Joint, bone, spine : revue du rhumatisme

The genetics of spondyloarthropathies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Joint, bone, spine : revue du rhumatisme - 20 Mar 2006

Breban M, Miceli-Richard C, Zinovieva E, Monnet D, Said-Nahal R

Link to Pubmed [PMID] – 16650794

Joint Bone Spine 2006 Jul;73(4):355-62

The spondyloarthropathies constitute a group of inflammatory joint diseases linked by shared characteristics that include a strong common genetic background. Genetic factors include major histocompatibility complex (MHC) genes, among which HLA-B27 contributes 30% of the overall genetic susceptibility to spondyloarthropathies, and non-MHC genes, none of which have been identified to date. Genome screens have identified regions that may contain susceptibility genes for spondyloarthropathies. In particular, a locus on the long arm of chromosome 9 (9q31-34) was identified by two groups working independently from each other. Studies using the candidate gene approach ruled out a role for most of the tested genes, including CARD15/NOD2. However, several independent groups have reported significant associations between ankylosing spondylitis and the IL-1 gene cluster on the long arm of chromosome 2.

https://www.ncbi.nlm.nih.gov/pubmed/16650794