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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : The Journal of infectious diseases

The frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children

Team: Group: Immunity of human retroviral infections
Team: Oncogenic Virus Epidemiology and Pathophysiology
Team: Archived: Group: Daniel Scott-Algara
Team: Archived: Regulation of Retroviral Infections
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 07 Oct 2005

Buseyne F, Scott-Algara D, Bellal N, Burgard M, Rouzioux C, Blanche S, Riviere Y

Link to Pubmed [PMID] – 16235177

J. Infect. Dis. 2005 Nov;192(10):1781-6

Ex vivo interferon (IFN)- gamma -producing CD8 T cells specific for human immunodeficiency virus (HIV) Env, Gag, and Pol antigens were measured in the peripheral blood of 55 children not receiving highly active antiretroviral therapy (HAART) and 70 children receiving HAART. In children not receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was positively correlated with age and was not associated with plasma viral load or CD4 T cell levels. In children receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was directly correlated with plasma viral load, and its association with age remained significant. In conclusion, the frequency of HIV-specific IFN- gamma -producing CD8 T cells in children is primarily determined by both age and plasma viral load.