Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Publication : Chromatin Signaling and Neurological Disorders - 1st Edition. Series Volume Editors: Olivier Binda

The epigenetics of multiple sclerosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chromatin Signaling and Neurological Disorders - 1st Edition. Series Volume Editors: Olivier Binda - 07 Jun 2019

Tove Christensen, Christian Muchardt

Hardcover ISBN: 9780128137963

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) associated with inflammation, demyelination, and axon destruction. At present, no reliable cure is available for the disease, largely due to the complicated circumstances causing its onset. Although genetic susceptibility is now well documented, the disease is transmitted with non- Mendelian ratios and there is strong evidence of the implication of environmental factors, including an intriguing impact of latitude. Here, we will describe the disease and the mysteries associated with its onset, and then introduce some of the data suggesting that in patients with MS, chromatin structure and chromatin-dependent transcriptional regulation are out of balance. In this context, we will have a special interest for mechanisms of gene silencing relying either on DNA methylation or on binding of HP1 proteins to histone H3 methylated at lysine 9 (H3K9me). Finally, we will speculate on tracks that may improve our understanding of the disease, by taking into consideration the role of chromatin in the translation of environmental cues into gene expression.