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© Research
Publication : Current opinion in immunology

The development of LTi cells

Team: Microenvironment and Immunity
Member: Gérard Eberl
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 01 Mar 2012

Cherrier M, Eberl G

Link to Pubmed [PMID] – 22386930

Curr. Opin. Immunol. 2012 Apr;24(2):178-83

Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer’s patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor RORγt. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.