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© Research
Publication : The Journal of experimental medicine

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of experimental medicine - 12 Jun 2006

Hao Y, Legrand N, Freitas AA

Link to Pubmed [PMID] – 16769997

J. Exp. Med. 2006 Jul;203(7):1643-9

Positive selection in the thymus and peripheral T cell survival depend on T cell receptor (TCR)-major histocompatibility complex (MHC) interactions, but it is not yet clear if both events follow exactly the same rules. We studied peripheral T cell survival and clone sizes in conditions of progressive reduction of restricting MHC-bearing cells or progressive ablation of different MHC molecules. Different CD8(+) T cell clones/polyclonal populations showed different survival and/or lymphopenia-driven proliferation requirements. We could correlate clone sizes to the capacity of each TCR to interact with different types of MHC complexes. Thus, although repertoire selection in the thymus is mainly conditioned by the affinity of TCR-MHC interactions, peripheral selection is determined by TCR cross-reactivity to environmental ligands.

http://www.ncbi.nlm.nih.gov/pubmed/16769997